A cold knife cone biopsy is a procedure to get a sample of abnormal tissue from the cervix for further examination.

See also:

• Cervical punch biopsy
• Colposcopy-directed biopsy

This is a surgical procedure. It is done in the hospital while you are either sedated through an IV or general anesthesia. The purpose of this procedure is to diagnose and treat precancerous changes in the cervix.

A small cone-shaped sample of tissue is removed from the cervix and examined under a microscope for any signs of cancer. This biopsy may also be the treatment if the doctor removes all of the diseased tissue.

As with any procedure that is done under anesthesia, you will probably need to fast for 6 - 8 hours. You must sign an informed consent form. The procedure is done on the same day (outpatient) and a hospital stay is usually not needed.

After the procedure, you may have some cramping or discomfort for a week or so. For about 4 - 6 weeks avoid:

• Douching
• Sexual intercourse
• Using tampons

For 2 - 3 weeks after the procedure, you may have discharge that is:

• Bloody
• Heavy
• Yellow-colored

This test is only done if the health care provider knows or suspects that you have abnormal cells in the cervix.

It may be done if a biopsy of the cervix shows that you may have precancerous cells in the area or cervical cancer. A cold knife biopsy may also be done if a cervical biopsy cannot find the cause of an abnormal Pap smear.

There are no precancerous or cancerous cells in the cervix.

Most often, abnormal results mean that there is an area of precancerous or cancerous cells.

• Bleeding
• Incompetent cervix (which may lead to premature delivery)
• Infection
• Scarring of the cervix (which may cause painful menstrual periods, make it more difficult for doctors to read an abnormal Pap smear, and make it harder to become pregnant)

Katz VL, Lentz GM, Lobo RA, Gershenson DM. Comprehensive Gynecology. Philadelphia, Pa: Mosby; 2007.