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Nikolsky’s sign

Contents of this page:

Illustrations

Nikolsky's sign
Nikolsky's sign
Skin layers
Skin layers

Definition    Return to top

Nikolsky's sign is a skin condition in which the top layers of the skin slip away from the lower layers when slightly rubbed.

Considerations    Return to top

Nikolsky's sign is either positive or negative. A positive result may be present in several different medical conditions. People with a positive sign have loose skin that slips free from the underlying layers when rubbed. The area beneath is pink and moist and may be very tender.

Typically, your health care provider will test for this sign simply by twisting a pencil eraser against your skin. If positive, a blister will form in the area, usually within minutes.

Causes    Return to top

Home Care    Return to top

There is no home care for most conditions associated with a positive Nikolsky's sign -- most affected people are hospitalized.

When to Contact a Medical Professional    Return to top

Call your health care provider if you or your child develop loosening, redness, and blistering of the skin without an obvious cause.

What to Expect at Your Office Visit    Return to top

The conditions associated with Nikolsky's sign are serious, and most people are sent to the hospital. You will be asked for your medical history and given a physical examination. You may be given fluid and antibiotics through a vein (intravenously).

Your doctor may ask the following questions:

Update Date: 2/5/2008

Updated by: Kevin Berman, MD, PhD, Associate, Atlanta Center for Dermatologic Disease, Atlanta, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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